Inclusion body myositis (IBM) is an inflammatory and regressive muscle disease that creates painless weakening of muscle. IBM gets worse slowly and is often misdiagnosed as treatment-resistant polymyositis, another inflammatory muscle disease that makes muscle weakness. IBM also may be misdiagnosed as amyotrophic lateral sclerosis. Symptoms of the disease generally start after the age of 50, although the condition can happen earlier. IBM occurs more rapidly in men than in women and is the most popular muscle disease in people aged 50 and older.
Symptoms of Inclusion Body Myositis (IBM)
Symptoms of IBM, the onset of muscle weakness generally is gradual, happening over months or years. Dropping and tripping are typically the first noticeable symptoms of IBM. For some people, IBM starts with weakness in the hands. The symptoms of IBM people may have:
1) Difficulty with gripping, pinching, and buttoning.
2) A deficiency of the wrist and finger muscles.
3) Atrophy (shrinking or wasting) of the muscles of the forearms.
4) Weakness and visible wasting of the quadriceps muscles
5) A deficiency of the lower leg muscles, below the knees.
6) A lack of esophageal muscles, which can cause dysphagia (difficulty swallowing) in about 30 to 40 percent of patients.
7) A lack of other muscle groups as the disease progresses.
Inclusion Body Myositis Caused by
The cause of IBM is unknown. Because of the inflammation related to IBM, some doctors think the disease is a structure of autoimmune disorder. In this kind of sickness, the bodyâ€™s immune system goes away and hits its own tissues here, the muscles. Some experts have connected the cause of IBM to infection by a virus that has yet to be identified. Other researchers believe that the initial problem in IBM caused by an age-related inability of the muscle to deal with destructive chemicals.
Diagnosis of Inclusion Body Myositis
Doctors use a muscle biopsy to diagnose of IBM. After providing an anesthetic, a doctor takes a sample of tissue from one of the infected muscles to be looked at for the diagnosis of IBM in a laboratory.
When observed under the microscope, the muscle cells of persons with IBM contain vacuoles. Within the vacuoles, there are generally abnormal clumps of many proteins, including one called amyloid. The protein clumps, or inclusion bodies, offer IBM its name. This is the hallmark of IBM diagnosis
Treatment of Inclusion Body MyositisÂ
There is no beneficial course of treatment for IBM. Some proof recommends that intravenous injection may help slightly in a small number of cases, but the outcome does not long-lasting. This is one treatment of IBM.
Physical therapy may be beneficial in the treatment of IBM for maintaining mobility and helping to stay joints mobile. Other treatment, including procedures for the swallowing complications, is the treatment of IBM. It is symptomatic and supportive.